Adding a certain compound to certain chemical reactions, such as: 26621-44-3, name is 3-Nitro-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 26621-44-3, Formula: C3H3N3O2
To a solution of compound 1 (25.0 g, 0.22 mol, 1.0 eq) in THF (250 mL) under Ar protection was added NaH (60%, 9.7 g, 0.24 mol, 1.1 eq) in portions.After stirring at room temperature for 10 min, SEMCl (44.2 g, 0.27 mol, 1.2 eq) was added dropwise.Stir overnight at room temperature.The reaction was quenched with saturated aqueous NH4Cl.The reaction solution was diluted with EtOAc, washed with water, dried over anhydrous Na2SO4, and concentrated under reduced pressure.Purification by column (PE / EtOAc = 5/1) gave compound 2 (36.3 g, 67%) as a white solid.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Nitro-1H-pyrazole, and friends who are interested can also refer to it.
Reference:
Patent; Longtaishen Pharmaceutical (Nanjing) Co., Ltd.; Yang Lei; (45 pag.)CN110590747; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics