155377-19-8, name is Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Ethyl 3-(trifluoromethyl)pyrazole-4-carboxylate
To lambda/-(5-(chloromethyl)-2,3-dihydro-7/-/-inden-1-yl)propane-2-sulfonamide (0.250 mmol, 72 mg) in DMF (4 ml.) was added ethyl 3-(trifluoromethyl)-7/-/-pyrazole-4-carboxylate (0.250 mmol, 52.1 mg) and Potassium carbonate (0.750 mmol, 104 mg). The resultant solution was heated to 60 0C with stirring. After 1.5 h the reaction mixture was concentrated to remove DMF before partitioning between EtOAc/H2O and the phases mixed and separated. The organic layer was washed with water (x 4) and brine before drying and concentration to a yellow oil. Purification on 10g Si eluting with 1% MeOH/DCM gave the desired compound as an off-white solid (60 mg, 0.131 mmol, 52.2 %). 1H NMR (400 MHz, CDCI3) delta 1.33 (t, 3H) 1.44 (d, 6H) 1.95 (m, 1 H) 2.65 (m, 1 H) 2.85 (m, 1 H) 3.00 (m, 1 H) 3.25 (m, 1 H) 4.15 (d, 1 H) 4.29 (q, 2H) 4.95 (m, 1 H) 5.30 (s, 2H) 7.14 (s, 1 H) 7.18 (d, 1 H) 7.48 (d, 1 H) 7.88 (s, 1 H).
The synthetic route of 155377-19-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; N.V. ORGANON; WO2009/147167; (2009); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics