Adding a certain compound to certain chemical reactions, such as: 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1192-21-8, category: pyrazoles-derivatives
Compound VIII-1 (200 mg, 0.48 mmol) and1-methyl-1H-pyrazole-5-amine (IX-2) (71 mg,0.73mmol) dissolved in tetrahydrofuran (5mL), cooled to -25 C, added 1N LiHMDS (0.73ml, 0.73mmol), reacted at -25 C for about 3h, to be detected by TLC (dichloromethane: methanol = 25:1) The raw material VIII-1 is completely reacted, and the solvent is evaporated under reduced pressure.The residue was subjected to column chromatography (dichloromethane:methanol = 150:1) to afford white powder (yield: 25.1%
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazol-5-amine, and friends who are interested can also refer to it.
Reference:
Patent; China Pharmaceutical University; Xu Yungen; Ji Dezhong; Zhang Lingzhi; Zhu Qihua; Bai Ying; Wu Yaoyao; (41 pag.)CN109608444; (2019); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics