Electric Literature of 3524-32-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3524-32-1 as follows.
General procedure: A stirred mixture of 1-substituted 5-aminopyrazole 2 (2.5 mmol), dichloro compound 1 (3.3 mmol), and acetonitrile (5 mL) was warmed gently to dissolve the starting materials and then cooled in an ice/water bath. Triethylamine (0.70 mL, 5 mmol) was added dropwise and the resulting mixture was stirred at room temperature or 50C until conversion was no longer observed by TLC. The reaction mixture was diluted slowly with water (20 mL) and extracted with dichloromethane. The crude product was chromatographed over silica gel and the product was recrystallised.
According to the analysis of related databases, 3524-32-1, the application of this compound in the production field has become more and more popular.
Reference:
Article; Norman, Rebecca E.; Perkins, Michael V.; Liepa, Andris J.; Francis, Craig L.; Australian Journal of Chemistry; vol. 68; 9; (2015); p. 1455 – 1466;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics