Synthetic Route of 1089212-38-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1089212-38-3, name is 4-Bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.
23. Preparation of N-(2-(2-cyclopropylcyclopropyl)phenyl)-3-difluoromethyl-1-methylpyrazole-4-carboxamide in the presence of 2,2-dimethyl-1,3-bis(diphenyl-phosphino)propane (Pepstar)A solution of Pd(PhCN)2Cl2 (0.014 mmol) and Pepstar (0.042 mmol) in dimethyl-formamide (DMF, 3 ml) was stirred at room temperature for 30 minutes. The solution comprising the pre-formed catalyst was transferred into an inertized autoclave. In a CO countercurrent, diazabicycloundecene (DBU, 3.08 mmol) and solutions of 3-difluoro-methyl-1-methyl-4-bromopyrazole (2.8 mmol) and 2-(2-cyclopropylcyclopropyl)aniline (2.8 mmol) in DMF (3.25 ml each) were added to the solution of the catalyst in the autoclave. The reaction mixture was shaken at room temperature for 10 min and at 150 C. and a CO pressure of 15 bar for a further 16 h.The conversion based on bromopyrazole was 97.6% at a selectivity of 83.4%. The composition of the reaction discharge was, according to GC analysis, as follows: DMF 33.51 area %, bromopyrazole 0.83 area %, DBU 31.65 area %, 2-(2-cyclopropylcyclo-propyl)aniline 0.0 area %, N-(2-(2-cyclopropylcyclopropyl)phenyl)-3-difluoromethyl-1-methylpyrazole-4-carboxamide 28.37 area %.Work-up was carried out as described in example 2.i), giving an isolated yield of N-(2-cyclopropylcyclopropyl)phenyl)-3-difluoromethyl-1-methylpyrazole-4-carboxamide of 81.4%
The chemical industry reduces the impact on the environment during synthesis 4-Bromo-3-(difluoromethyl)-1-methyl-1H-pyrazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; BASF SE; US2010/174094; (2010); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics