Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1353100-91-0, name is Ethyl 3-bromo-1H-pyrazole-4-carboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C6H7BrN2O2
Under anhydrous N, N- dimethylformamide (5 mL) with ethyl 3-bromo -1Hpyrazole-4-carboxylate(1.87 mmol) cooling bath (ice-bath) stirred in a solution ofsodium hydride It was added (60% dispersion in paraffin, 2.81 mmol). 15After minutes,1- (chloromethyl) -4-methoxybenzene was added (2.24 mmol), followed by allowingthe mixture to room temperature. After overnight, concentrated and then stop thereaction with water. The residue (residue) generated as a result is diluted withdichloromethane, the organic solution was washed with water and brine andconcentrated after drying over anhydrous MgSO4. Crude residue (crude residue) andpurified by silica gel flash column chromatography gave the B1.
The synthetic route of 1353100-91-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Qurient Co., Ltd.; Institut Pasteur Korea Foundation; Kim, Jae Sung; Kang, Sun Hee; Lee, Say Yeon; Saw, Min Jung; Saw, Moo Young; Saw, Jung Jae; Lee, Su Mi; Kim, Jun Won; Choe, In Hee; Ko, Yun Aey; Jo, Su Yeon; Kwon, Jung Jin; Hwang, Jong Yeon; Lee, Jae Hun; Kang, Ju Hee; Lee, Jin Hwa; Han, Sung Jun; Kim, Jung Hwan; Lee, Sang Chul; Choe, Ga Hee; Lee, Yun Mi; Nam, Gi Yeon; (49 pag.)KR101480674; (2015); B1;,
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