Electric Literature of 162758-35-2,Some common heterocyclic compound, 162758-35-2, name is 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, molecular formula is C17H11Cl3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: To a solution of the carboxylic acid (1 eq) in dry dichloromethane, was added N-(3-Dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (EDC.HCl, 1.2 eq), Hydroxybenzotriazole (1.2 eq) and diisopropylethyl amine (3 eq) at 0C. Then the amine (1.1 eq) was added and stirred at RT for 6h. To the reaction mixture, water was added and the organic layer was separated, washed with saturated NaHCO3, 1N HCl, dried over Na2SO4 and concentrated under reduced pressure. This crude mixture was purified by column chromatography to give the pure compound.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-(4-Chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxylic acid, its application will become more common.
Reference:
Article; Ramesh, Remya; Shingare, Rahul D.; Kumar, Vinod; Anand, Amitesh; B, Swetha; Veeraraghavan, Sridhar; Viswanadha, Srikant; Ummanni, Ramesh; Gokhale, Rajesh; Srinivasa Reddy; European Journal of Medicinal Chemistry; vol. 122; (2016); p. 723 – 730;,
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