175277-11-9, name is 3-tert-Butyl-1-methylpyrazole-5-carboxylic Acid, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H14N2O2
3-tert-butyl-1-methyl-1H-pyrazole-5-carboxylic acid (0.090 g, 0.49 mmol) was dissolved in CH2Cl2 (5 mL). DMAP(0.005 g, 0.04 mmol) and EDC (0.163 g, 0.85 mmol) were added, and the mixture was stirred for15 min at room temperature. The TFA salt was suspended in CH2Cl2 (3 mL) and treated withtriethylamine (136 muL, 0.98 mmol) at 0C. The resulting mixture was dropwise combined withthe activated acid and stirred for 18 h at room temperature. The solvent was evaporated under reduced pressure. The residue was treated with H2O and extracted with ethyl acetate (3 × 10 mL).The combined organic layers were washed with sat. NaHCO3 (3 × 10 mL), H2O (20 mL), andbrine (20 mL). The solvent was dried over MgSO4 and removed under reduced pressure. Thecrude residue was purified by silica column chromatography using EtOAc as eluent to obtain C(33 % yield).
The synthetic route of 175277-11-9 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Silva, Daniel G.; Ribeiro, Jean F.R.; De Vita, Daniela; Cianni, Lorenzo; Franco, Caio Haddad; Freitas-Junior, Lucio H.; Moraes, Carolina Borsoi; Rocha, Josmar R.; Burtoloso, Antonio C.B.; Kenny, Peter W.; Leitao, Andrei; Montanari, Carlos A.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 22; (2017); p. 5031 – 5035;,
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