Application of 330792-70-6, These common heterocyclic compound, 330792-70-6, name is 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5-amino-3-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile (1.5 g, 5.4 mmol)And a mixture of K2CO3 (2.24 g, 16.3 mmol) in DMF (50 mL),Stir for 45 minutes under nitrogen at 80C.Then, tert-butyl 3-bromo-4-oxopiperidine-1-carboxylate (4.5 g, 16.3 mmol) was added in one portion.The reaction mixture was stirred at 80 C for 1 h.It was then cooled to room temperature and water (150 mL) and EA (150 mL) were added.The aqueous phase was further extracted with EA (100 mL x 3) and the combined organic phases were washed with saturated brine, dried over Na2SO4, concentrated, and purified on a tannin extract column (15 g of silica gel, DCM/MeOH = 400/1 to 200/1).An off-white solid product 3-cyano-2-(4-phenoxyphenyl)-5,6-dihydro-4H-pyrazolo[5′,1′:2,3]imidazo[4, 5-c]tert-Butyl pyridine-7(8H)-carboxylate (850 mg, 35%).
Statistics shows that 3-Amino-5-(4-phenoxyphenyl)pyrazole-4-carbonitrile is playing an increasingly important role. we look forward to future research findings about 330792-70-6.
Reference:
Patent; BEIGENE, LTD; WANG, ZHIWEI; GUO, YUNHANG; (300 pag.)TWI602818; (2017); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics