In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1192-21-8, name is 1-Methyl-1H-pyrazol-5-amine belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C4H7N3
3rd generation BrettPhos pre-catalyst (0.227 g, 0.25 mmol) was added to methyl i-(i((tert-butoxycarbonyl)amino)-3 -methoxypropan-2-yl)-4-(2-chloro-5 -methylpyrimidin-4- yl)-1H-pyrrole-2-carboxylate (1.1 g, 2.51 mmol), i-methyl-1H-pyrazol-5-amine (0.487 g, 5.01 mmol) and cesium carbonate (2.041 g, 6.27 mmol) in 1,4-dioxane (30 mL) at 25 °C under nitrogen. The resulting solution was stirred at 85 °C for 3 hours. The reactionmixture was poured into water (25 mL), extracted with EtOAc (3 x 50 mL), the organic layer was dried over Na2SO4, filtered and evaporated to afford crude yellow solid. The crude product was purified by flash silica chromatography, elution gradient 80 to 90percent EtOAc in petroleum ether. Pure fractions were evaporated to dryness to afford methyl 1 -(1- ((tert-butoxycarbonyl)amino)-3 -methoxypropan-2-yl)-4-(5 -methyl-2-(( i-methyl-i H25 pyrazol-5-yl)amino)pyrimidin-4-yl)-1H-pyrrole-2-carboxylate (0.700 g, 55.9 percent) as a whitefoam. mlz: ES+ [M+H]+ 500.
The synthetic route of 1192-21-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WARD, Richard, Andrew; GRAHAM, Mark, Andrew; SWALLOW, Steven; JONES, Clifford, David; (282 pag.)WO2016/162325; (2016); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics