Application of 113100-53-1, A common heterocyclic compound, 113100-53-1, name is 1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-carboxylic acid, molecular formula is C6H5F3N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: Intermediate 5 (1.0 mmol) and 4-dimethylaminopyridine (0.1 mmol) were added to a mixture of the corresponding carboxylic acid 6 (1.3 mmol) and (EDCI, 2 mmol) in CH2Cl2 (20 mL). The reaction system was stirred at room temperature overnight and then diluted with CH2Cl2 (50 mL). The resulting mixture was consecutively washed with 10% citric acid solution and brine. Then the organic phase was dried with sodium sulphate and filtered, and concentrated under reduced pressure. The residue was purified on a silica gel column to afford the title compounds 7-17.
The synthetic route of 113100-53-1 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Xiong, Li; Zhu, Xiao-Lei; Shen, Yan-Qing; Kandergama Wasala Mudiyanselage Wishwajith, Wickramabahu; Li, Kui; Yang, Guang-Fu; European Journal of Medicinal Chemistry; vol. 95; (2015); p. 424 – 434;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics