Electric Literature of 852227-86-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 852227-86-2, name is 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole, This compound has unique chemical properties. The synthetic route is as follows.
10171] Step 4. A mixture ofD-15 (210 mg, 0.78 mmol) and cesium carbonate (765 mg, 2.35 mmol) in DMF (25 mL) was heated to 60 C. with stirring then a solution of 5-(chlorom- ethyl)-1,3-dimethyl-1H-pyrazole (113 mg, 0.78 mmol) in DMF (10 mL) was added drop wise. The reaction mixture was stirred for 1 hour at 60 C. The solids were removed by filtration and the solvent was removed under reduced pressure. Crude D-16 was used as such in the next step.10172] LC-MS: Anal. Calcd. For C18H28N503: 376.22; found 377 [M+H]
The chemical industry reduces the impact on the environment during synthesis 5-(Chloromethyl)-1,3-dimethyl-1H-pyrazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; McGowan, David; Raboisson, Pierr Jeane-Marie Bernar; Embrechts, Werner; Jonckers, Tim Hugo Maria; Last, Stefaan Julien; Pieters, Serge Maria Aloysius; Vlach, Jaromir; US2014/45849; (2014); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics