Adding a certain compound to certain chemical reactions, such as: 2458-26-6, name is 3-Phenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2458-26-6, name: 3-Phenyl-1H-pyrazole
Methyl 3-(3-phenyl- 1 H -pyrazol- 1 -yl)butanoate 3-Phenyl-1 H-pyrazole (250 mg, 1 .73 mmol), methyl crotonate (275 muIota, 2.60 mmol) and DBU (130 muIota, 0.87 mmol) were combined in acetonitrile (3.5 ml), under nitrogen. The reaction was stirred at 50 C for 18 h and by TLC the reaction was complete. All of the volatiles were removed in vacuo and the crude material was purified by column chromatography, eluting 15-25% ethyl acetate/petroleum spirits. The title compound was obtained as a colourless oil [32] mg, 76%). HPLC – rt 7.48 min > 98% purity at 254 nm; LRMS [M+H]+ 245.2 m/z; HRMS [M+H]+ 245.1285 m/z, found 245.1284 m/z; 1 H NMR (400 MHz, DMSO) delta 7.87 – 7.70 (m, 3H), 7.44 – 7.33 (m, 2H), 7.33 – 7.19 (m, 1 H), 6.66 (d, J = 2.3 Hz, 1 H), 4.93 – 4.62 (m, 1 H), 3.56 (s, 3H), 2.93 (ddd, J= 22.0, 16.0, 7.0 Hz, 2H), 1 .48 (d, J = 6.8 Hz, 3H); 13C NMR (101 MHz, DMSO) delta 170.8, 149.7, 133.5, 130.3, 128.6 (2C), 127.3, 125.0 (2C), 102.2, 54.0, 51 .5, 40.5, 20.9.
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Reference:
Patent; MONASH UNIVERSITY; THE UNIVERSITY OF WESTERN AUSTRALIA; BAELL, Jonathan; PIGGOTT, Matthew; RUSSELL, Stephanie; TOYNTON, Arthur; RAHMANI, Raphael; FERRINS, Lori; NGUYEN, Nghi; (178 pag.)WO2015/172196; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics