Related Products of 5744-40-1, A common heterocyclic compound, 5744-40-1, name is Ethyl 1,3-dimethyl-1H-pyrazole-5-carboxylate, molecular formula is C8H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Lithium aluminum hydride(l.OM in tetrahydrofuran, 1.78 mL) solution was added to commercially available ethyl 1,3-dimethyl-l//-pyrazole-5-carboxylate (Jl, 300 mg, 1.78 mmol) in tetrahydrofuran over 5 minat room temperature. The reaction stirred overnight. In succession water (67 |j,L), 15%aqueous sodium hydroxide (202 uL), water (67 |aL) were added. The resulting solid wasfiltered and dried in vacua, then purified by chromatography (3% to 7% methanol indichloromethane) to yield 175 mg of a colorless solid, J2.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; AMGEN INC.; WO2006/4915; (2006); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics