Related Products of 31108-57-3,Some common heterocyclic compound, 31108-57-3, name is 1H-Pyrazole-4-carbonitrile, molecular formula is C4H3N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a microwave tube propan-2-yl (2R)-oxirane-2-carboxylate (2.00 g, 15.4 mmol) and 4- cyanopyrazole (3.58 g, 38.4 mmol) were dissolved in isopropanol (10 ml). The RM was heated in a microwave reactor at 100C for 3 h. The RM was concentrated in vacuo, then purified by prep-HPLC: (column: Agela Innoval ODS-2 100mm*350mm; mobile phase: [water (0.1 % TFA) – ACN]; B %: 5 % – 25 %, 20 min) to obtain the title compound as a yellow oil. MS ES+: 224.2. NMR (400MHz, chloroform-) delta 7.94 (s, 1H), 7.78 (s, 1H), 5.13 – 5.06 (m, 1H), 4.51 – 4.48 (m, 2H), 3.72 (s, 1H), 1.32 – 1.26 (m, 6H).
The synthetic route of 31108-57-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NODTHERA LIMITED; BOCK, Mark G.; WATT, Alan Paul; PORTER, Roderick Alan; HARRISON, David; (229 pag.)WO2019/25467; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics