Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 18213-75-7, name is 5-Amino-1-methyl-1H-pyrazole-4-carboxamide, A new synthetic method of this compound is introduced below., Formula: C5H8N4O
The mixture of 5-amino-1-methyl-1H-pyrazole-4-carboxamide (70 g, 0.49 mol), EtONa (117 g, 1.72 mol) and the intermediate from Step B ( (272 g, 1.16 mol) in EtOH (1 L) was stirred in a sealed bottle at 120C overnight. The mixture was concentrated and the residue was diluted with H2O (2 L) and then adjusted to pH = 6 with 2 N aqueous HC1 solution. The mixture was extracted with EtOAc (1 L x 3). The combined organic layer was dried over Na2SO4, filtered and concentrated. The residue was purified by silica gel column chromatography using petroleum ether/EtOAc = 1 : 1 to give the title product.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK SHARP & DOHME CORP.; HAN, Xiaoqing; WHITEHEAD, Alan; RAGHAVAN, Subharekha; CERNAK, Timothy, A.; DREHER, Spencer; GROEPER, Jonathan; GUO, Jian; ZHANG, Yong; WO2015/88886; (2015); A1;,
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