Related Products of 139308-52-4, These common heterocyclic compound, 139308-52-4, name is Ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[1302] to a solution of ethyl 3-bromo-1-methyl-1H-pyrazole-4-carboxylate (500 mg, 2.15 mmol) and NCS (574 mg, 4.30 mmol) was stirred. The mixture was stirred at 160 C for 3h under N2. The reaction mixture was added by addition of cc (20 ml), and then diluted with NaHCO3 (30 ml). The mixture was extracted with DCM (20 ml x 3). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure to give a residue. The residue was purified by preparatory- tlc (SiO2, pe:ea = 5: 1). Compound 274a (180 mg, yield: 31.30%) was obtained as a yellow oil. 1H NMR (400mhz, CDCl3) delta 4.34 (q, = 7.1 hz, 2h), 3.85 (s, 3h), 1.46 – 1.24 (m, 3h). MS (ESI) m/z (M+H)+266.9.
The synthetic route of 139308-52-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics