Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 398491-59-3, name is tert-Butyl 3-amino-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate, A new synthetic method of this compound is introduced below., SDS of cas: 398491-59-3
A solution of ethyl chlorocarbonate (8. 9 ml, 93 MMOL) in tetrahydrofuran (THF, 250 ml) was slowly added to a mixture of tert-butyl 3-AMINO-4, 6-dihydropyrrolo [3, 4-CPYRAZOLE-5 (1 H)- CARBOXYLATE (20 G, 89 MMOL) and diisopropylethylamine (DIEA, 92 ml, 528 MMOL) in THF (500 ML) at 0-5 C. The reaction was kept at the same temperature for two hours then allowed to reach room temperature and stirred overnight. The obtained mixture was evaporated to dryness under vacuum, and the resulting residue extracted with ethyl acetate (AcOEt) and water. The organic layer was separated, dried over sodium sulfate and evaporated to dryness. The mixture was purified by flash-chromatography (eluent : ethyl acetate/cyclohexane 4/6 to 7/3) to give 19 G of the title compound as a white solid. [M+H] + 297
The synthetic route of 398491-59-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PHARMACIA ITALIA S.P.A.; WO2005/5427; (2005); A1;,
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