These common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 175137-46-9
The solution of 1,3,5-trifluoro-2-nitrobenzene (6.50 g, 37 mmol), 5-cyclopropyl-1H- pyrazol-3-amine (3.50 g, 28 mmol) and DIEA (6.4 ml, 37 mmol) in THF (100 ml) was stirred at 25 C for 80 hours. The solvent was removed under reduced pressure and the residue was purified by chromatography (DCM-EtOAc = 10 : 1) to give the title compound as yellow solid (4.9 g, 62%). NMR (400 MHz) 12.26 (s, 1H), 9.09 (s, 1H), 7.70 (d, J= 12.8 Hz, 1H), 6.88 (m, 1H), 5.80 (s, 1H), 1.88 (m, 1H), 0.93 (m, 2H), 0.69 (m, 2H).
The synthetic route of 5-Cyclopropyl-1H-pyrazol-3-amine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/103010; (2005); A2;,
Pyrazole – Wikipedia,
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