In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 120068-79-3 as follows. Recommanded Product: 120068-79-3
In 100 mLReactor30 mL of N, N-dimethylformamide,6.6 g of 1- (2,6-dichloro-4-trifluoromethyl) phenyl-3-cyano-5-aminopyrazole,2.5 g of triethylamine,2.09 g of 1,4-cyclohexanedionyl chloride,After mixing,Put the reactor into the oven,The reaction temperature was 160 C,The reaction time was 360 minutes.After completion of the reaction,The solvent was removed by rotary evaporation,Adjust the pH to neutral,extraction,After drying over anhydrous magnesium sulfate,(Petroleum ether and ethyl acetate (4: 1)) to obtain 6.47 g of (II) 6 as a pale yellow solid,The yield was 83.1% .
According to the analysis of related databases, 120068-79-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; South Central University for Nationalities; Chen, Lianqing; Zhou, Quan; Niu, Xionglei; (17 pag.)CN105693612; (2016); A;,
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