In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57012-20-1, name is (1,3-Dimethyl-1H-pyrazol-5-yl)methanol belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C6H10N2O
2-((l,3-dimethyl-lH-pyrazol-5-yl)methoxy)-5-fluoronicotinic acid (21x)To a solution of 2-chloro-5-fluoronicotinic acid (1.0g, 5.7mmol) in THF (20ml) under a N2 atmosphere was added (l,3-dimethyl-lH-pyrazol-5-yl)methanol (l .Og, 8.0mmol) followed by a portion-wise addition of NaH (60% dispersion in mineral oil, 0.68g, 17mmol). The resulting suspension was stirred at 70C for 16h and then cooled to room temperature and quenched with 1M NaOH (15ml). After washing with DCM (x2), the aqueous layer was acidified with concentrated HC1 until the product precipitated out of solution (~ pH 5). The solids were filtered, washed with ¾0 and then dried under high vacuum to afford the title compound(1.34g, 89%) as a white solid.NMR delta 8.37 (1H, d, J 3.1), 8.02 (1H, dd, J 8.2, 3.1), 6.10 (1H, s), 5.36 (2H, s), 3.75 (3H, s), 2.08 (3H, s);MS (m/e) 266 [M+H]+, Rt 0.71min (QC Method 1)
The synthetic route of 57012-20-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; ASTRAZENECA UK LIMITED; BARNES, Michael, Christopher, Stratton; FLACK, Stephen, Sean; FRASER, Ian; LUMLEY, James, Andrew; PANG, Pui Shan; SPENCER, Keith, Charles; TIBERGHIEN, Nathalie, Anne, Laure; TOMKINSON, Gary, Peter; WO2011/151651; (2011); A1;,
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