Adding a certain compound to certain chemical reactions, such as: 20055-01-0, name is 1-Methyl-1H-pyrazole-4,5-diamine sulfate, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 20055-01-0, Computed Properties of C4H10N4O4S
To a solution of (2S)-2- [ (BENZYLOXYCARBONYL) AMINO]-5- [ (TERT- butoxycarbonyl) amino] pentanoic acid (22.0 g) and triethylamine (6.7 g) in tetrahydrofuran (240 ml) was added methyl chloroformate (6.2 g) followed by stirring under ice-cooling for 30 minutes. To the reaction mixture was added a solution of 1-METHYL-LH-PYRAZOLE- 4,5-diamine sulfate (12.6 g) and triethylamine (13.4 g) in water (50 ml) at the same temperature. The mixture. was stirred at the room temperature for 1 hour. To the reaction mixture was added chloroform (240 ml), and the layers were separated. The organic layer was washed successively with 10% aqueous citric acid solution, brine and saturated aqueous sodium hydrogencarbonate solution. The organic layer was dried over anhydrous magnesium sulfate, filtered and concentrated in vacuo to give a crude product of 1-benzyl 4-tert-butyl { (1S)-1- [ (5-amino-l-methyl-lH-pyrazol-4- yl) carbamoyl] tetramethylene} biscarbamate as an oil. The crude product was used directly in the next step without further purification. A solution of the crude product of 1-benzyl 4- tert-butyl {(LS)-1-[(5-AMINO-1-METHYL-LH-PYRAZOL-4- yl) carbamoyl] tetramethylene} biscarbamate in methanol (200 ml) was treated with 10% palladium on carbon (1.0 g) under a hydrogen atmosphere at room temperature for 6 days. After the catalyst was filtered off, the filtrate was concentrated in vacuo. The residue was triturated with ether and dried in vacuo to give tert-butyl (4S)-4- AMINO-5- [ (5-AMINO-1-METHYL-LH-PYRAZOL-4-YL) AMINO]-5- oxopentylcarbamate (5.5 g) as a solid. 1H-NMR (CDC13) 8 1.40 (9H, s), 1.41 (9H, S), 1.42-1. 44 (4H, m), 2.33-2. 44 (2H, m), 2.85 (3H, s), 3.02-3. 40 (2H, m), 3.38-3. 39 (2H, m), 4.18-4. 20 (1H, m), 4.74 (1H, br), 4.76 (1H, s), 5.24 (1H,. br), 6.39 (1H, d, J = 7 Hz), 7.17 (1H, br), 7.18-7. 30 (15H, m), 7.52 (1H, s)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-pyrazole-4,5-diamine sulfate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; FUJISAWA PHARMACEUTICAL CO., LTD.; Wakunaga Pharmaceutical Co., Ltd.; WO2005/27909; (2005); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics