Synthetic Route of 881668-70-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 881668-70-8 as follows.
Add in 100mL round bottom flask5-chloro-1H-pyrazole-3-carboxylic acid (0.122 g, 0.8355 mmol),1.5 mL of anhydrous DMF as a solvent, Add EDCI (0.16 g, 1.0444 mmol), DIPEA (0.24 mL, 1.3926 mmol) and HOBT (32 mg, 0.2089 mmol), Stir for 20 minutes. Add another starting material (S)-3-amino-N-(4-cyano-3-trifluoromethyl-phenyl)-2-hydroxy-2-methylpropanamide (0.20 g, 0.6963 mmol) a solution of 4.0 mL of anhydrous DMF, Then the reaction solution is under argon protection. Stir at room temperature for 3 days. After confirming the completion of the reaction by thin layer chromatography, ethyl acetate and water were added, the two phases were separated, and the organic phase was drained to obtain Oily substance. Separation by silica gel column chromatography (mobile phase: methylene chloride:methanol = 9:1), purified to give pale yellow powder 0.15 g, the yield was about 51.0%.
According to the analysis of related databases, 881668-70-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Yang Guohong; He Junze; Duan Meijuan; (34 pag.)CN108558760; (2018); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics