930-36-9, name is 1-Methylpyrazole, belongs to pyrazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 1-Methylpyrazole
To a solution of 1-methylpyrazole (6.0 g, 73.1 mmol)and N,N,N’,N’-tetramethylethylenediamine (10.96 mL, 73.1 mmol) in THF (125 mL),butyl lithium (2.69 M solution in hexane; 31.8 mL, 85.5 mmol) was added at -78C. The reaction solution was stirred at-78 C. for 30 minutes. Then,cyclohexanone (9.06 mL, 87.7 mmol) was added thereto, and the mixture wasstirred at room temperature for 15 hours. To the reaction solution, water (500mL) was added, followed by extraction with ethyl acetate (250 mL). The thusobtained organic layer was dried over anhydrous sodium sulfate. Afterconcentration under reduced pressure, the residue was purified with silica gelchromatography (hexane/ ethyl acetate=3:2) to yield the title compound (11.32g, 86%) as a colorless oil.
The synthetic route of 930-36-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Daichi Sankyo Corporation; Takahashi, Sakiko; Domon, Yuki; Kitano, Yutaka; Sinojika, Tsuyoshi; (102 pag.)KR2015/126620; (2015); A;,
Pyrazole – Wikipedia,
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