Related Products of 121507-34-4, The chemical industry reduces the impact on the environment during synthesis 121507-34-4, name is 5-Isopropoxy-1H-pyrazol-3-amine, I believe this compound will play a more active role in future production and life.
(Step 2) Production of 5-isopropoxy-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-pyrazole-3-amine With cooling with ice, sodium hydride (1.44 g) was added to a DMF (100 mL) solution of the compound (4.84 g) obtained in the step 1, and stirred for 2 hours with cooling with ice. The reaction liquid was cooled to -18 C., and 2-(trimethylsilyl)ethoxymethyl chloride (6.38 mL) was dropwise added thereto. After stirred at -18 C. for 2 hours, this was heated up to room temperature, and further stirred for 1 hour. Aqueous saturated ammonium chloride solution was added to the reaction liquid, then extracted with ethyl acetate, and dried with sodium sulfate. The drying agent was removed through filtration, and the solvent was evaporated off under reduced pressure. The residue was purified through silica gel column chromatography (ethyl acetate/hexane=from 0% to 40%, gradient, and then methanol/chloroform=from 0% to 20%, gradient) to give the entitled compound (2.28 g, 25%).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Isopropoxy-1H-pyrazol-3-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Jitsuoka, Makoto; Nagase, Tsuyoshi; Sato, Nagaaki; Tsukahara, Daisuke; US2011/9622; (2011); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics