Application of 114474-28-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 114474-28-1 as follows.
A mixture of 4-(lH-pyrazol-4-yl)aniline (120 mg, 0.75 mmol), 2,4-dichloro- 7-fluoroquinazoline (164 mg, 0.75 mmol), and zPrNEt2 (195 mg, 1.51 mmol) in DMF (2.51 mL) was stirred at 90 C overnight, cooled to rt, diluted with water. The precipitate formed was collected by filtration and washed with water and dried in vacuo to provide the title compound (245 mg, 96%). MS (ES+) m/e 340 (M+H)+.
According to the analysis of related databases, 114474-28-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; KADMON CORPORATION, LLC; KIM, Ji-ln; OLSZEWSKI, Kellen, L.; BARSOTTI, Anthony, M.; POYUROVSKY, Masha, V.; LIU, Kevin, G.; MORRIS, Koi; YU, Xuemei; (129 pag.)WO2018/201006; (2018); A1;,
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