Adding a certain compound to certain chemical reactions, such as: 121507-34-4, name is 5-Isopropoxy-1H-pyrazol-3-amine, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 121507-34-4, Safety of 5-Isopropoxy-1H-pyrazol-3-amine
Method 2; 2,5-Dichloro-N-(5-isopropoxy-lH-pyrazol-3-yl)pyrimidin-4-amine; A solution of 2,4,5-trichloropyrimidine (533 mg, 2.93 mmol), 5-isopropoxy-lH- pyrazol-3 -amine (413 mg, 2.93 mmol) and triethylamine (0.49 ml) in TetaF (5 ml) was stirred at room temperature for 10 hours. Solvent was removed and EtOAc was added. The solution was washed with water and dried over anhydrous sodium sulfate and was concentrated to give title compound as a white solid (582 mg, 69%). LC-MS, 246 (M-42); 1H nuMR (CDCl3) delta 8.19 (s, IH), 7.80 (s, IH)5 5.79 (s, IH), 4.65 (m, IH), 1.30 (d, 6H).
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Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/49041; (2007); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics