Reference of 175137-46-9,Some common heterocyclic compound, 175137-46-9, name is 5-Cyclopropyl-1H-pyrazol-3-amine, molecular formula is C6H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2,4-dichloropyrimidine 2 (13.30 g, 89.31 mmol) and 3-amino-5-cyclopropylpyrazole 1 (11.00 g, 89.31 mmol) were dissolved in tetrahydrofuran (TFA) (100 ml) followed by theaddition of deionized water (100 ml). The solution was then treated with potassium acetate (261.9 g, 2.5 mol). The resulting mixture was kept at 55C for 48 h. The mixture was filtered to remove excess potassium acetate. The organic layer was separated and dried using magnesium sulfate and concentrated before loading on an AnaLogix silica column. Intermediate 3 was separated as previously reported (34). ?H NMR (400 MHz, DMSO) oe 12.14 (s, 1H), 10.23 (s,1H), 1.84 (m, 1H), 0.88 (m, 2H), 0.64 (m, 2H). ?3C NMR (100 MHz, DMSO) oe 161.4, 160.7,160.0, 153.9, 148.6, 147.8, 146.8, 8.4, 8.2. MS calculated for C,0H,0N5 235.06, found 236.15 (M).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Cyclopropyl-1H-pyrazol-3-amine, its application will become more common.
Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; SHOKAT, Kevan, M.; MENDEZ, Aaron, S.; (131 pag.)WO2016/22839; (2016); A1;,
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