Related Products of 17635-44-8, These common heterocyclic compound, 17635-44-8, name is 3,4,5-Tribromopyrazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of D183 (0.95 g, 8.3 mmol) in THF (50mL) was added 3,4,5-tribromo-1 H- pyrazole (2.8 g, 9.1 mmol), PPh3 (4.3 g, 16.6 mmol) and DEAD (3.6 g, 20.7mmol) at 0-5 C under N2. The reaction solution was stirred at rt for 16 hrs. The reaction solution was poured into water (50 mL) and extracted with EtOAc (100 ml_x2). The combined organic layer was washed with brine, dried over anhydrous Na2S04and concentrated in vacuo. The crude product was purified by gel silica column chromatography (PE:EtOAc from 50:1 to 10:1 ) to afford the title compound as yellow oilsolid (2.4g, yield 71.6 %). LC-MS 403.0 (M+H)+.
The synthetic route of 17635-44-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; DING, Xiao; HO, Ming-Hsun; REN, Feng; YU, Haihua; ZHAN, Yang; (290 pag.)WO2019/12093; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics