Electric Literature of 20154-03-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20154-03-4 as follows.
To a stirred solution of 10 g (73.5 mmol) 3-(trifluoromethyl)-1H-pyrazole (3) in DMSO (150 ml) were added 9.9 g of potassium tert.-butoxide portion wise. After stirring for 5 minutes drop wise addition of 12 ml of iodoethane followed by stirring overnight were conducted. Water was added afterwards and the pH value was adjusted to 3 by using 1N HCl. The mixture was diluted with MTBE and extracted two more times with MTBE. The combined organic phase was washed with Na2S2O3-solution, water and brine yielding 8 g (67 percent) of the ionic liquid 8.
According to the analysis of related databases, 20154-03-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SOLVAY SA; Braun, Max Josef; Fischer, Reiner; EP2662359; (2013); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics