Reference of 37622-90-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 37622-90-5 as follows.
To a solution of 20 (14.0 g, 100 mmol) and NaOAc (32.8 g,400 mmol) in EtOH/H2O (200 mL, v/v, 2/3) was added Br2 (39.95 g,250 mmol) at room temperature. The mixture was stirred at room temperature for 10 h. After addition of Na2S2O3 (31.62 g, 200 mmol)was added and the resulting mixture was then concentrated to afford the crude product, the mixture was poured into H2O at room temperature and was extracted with EtOAc. The organic layer was separated,washed with brine, dried over anhydrous sodium sulfate, and the solvent was evaporated under reduced pressure to give 21 (26.6 g,92%) as a pale yellow solid. MS (ESI) m/z: 296.7 [M+H]+.
According to the analysis of related databases, 37622-90-5, the application of this compound in the production field has become more and more popular.
Reference:
Article; Yin, Yuan; Chen, Cheng-Juan; Yu, Ru-Nan; Shu, Lei; Zhang, Tian-Tai; Zhang, Da-Yong; Bioorganic and Medicinal Chemistry; vol. 27; 8; (2019); p. 1562 – 1576;,
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