Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 39806-90-1, name is 4-Iodo-1-methyl-1H-pyrazole, A new synthetic method of this compound is introduced below., Application In Synthesis of 4-Iodo-1-methyl-1H-pyrazole
To a solution of 4-amino- 1 -methyl -pyrrolidin-2-one (100 mg, 0.88 mmol) in toluene (2 ml) was added 4-iodo- 1 -methyl-pyrazole (200 mg, 0.96 mmol), sodium tert-butoxide (168 mg, 1.75 mmol) and [2-(2-aminoethyl)phenyl]-chloro-palladium;ditert-butyl-[2- (2,4,6- triisopropylphenyl)phenyl]phosphane (also known as tBuXPhos Pd Gl) (60 mg, 88 pmol), then the mixture was stirred at 100 C for 3 h. The mixture was concentrated under reduced pressure. The residue was purified by prep-HPLC (column: Waters Xbridge Prep OBD C18 5pm 150×30; mobile phase: [water (0.1 % TFA) – ACN]; B: 1 – 30 %,l0 min) to give the title compound as colourless gum (Y = 20 %). ‘H NMR (400 MHz, methanol-*) d ppm 7.63 (s, 1H), 7.43 (s, 1H), 4.17 – 4.05 (m, 1H), 3.87 (s, 3H), 3.84 – 3.76 (m, 1H), 3.43 (dd, J= 3, 11 Hz, 1H), 2.90 – 2.79 (m, 4H), 2.41 (dd, j= 3, 18 Hz, 1H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; NODTHERA LIMITED; HARRISON, David; WATT, Alan Paul; BOCK, Mark G.; (334 pag.)WO2019/121691; (2019); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics