Adding a certain compound to certain chemical reactions, such as: 10199-68-5, name is 4-Phenyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10199-68-5, HPLC of Formula: C9H8N2
[0464] a mixture consisting of compound 21a (500 mg, 2.12 mmol), compound 21b (306 mg, 2.12 mmol) and Cs2CO3 (2.07 g, 6.36 mmol) was stirred at 110.6 C for 16 hrs. The reaction mixture was cooled to room- temperature, filtered and concentrated under reduced pressure to give a residue. The residue was purified by flash silica gel chromatography (petroleum ether: ethyl acetate = 3:2 and then acetic acid: ethyl acetate = 1: 100) to afford compound 21c (80 mg, 12.61% yield) as a light yellow solid, and compound 21d (125 mg, 21.73% yield) as a yellow solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Phenyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics