Adding a certain compound to certain chemical reactions, such as: 15802-75-2, name is 4-Iodo-3-methyl-1H-pyrazole, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 15802-75-2, COA of Formula: C4H5IN2
Under nitrogen protection,To a 10 ml Schlek reaction tube (a glass instrument commonly used in anhydrous oxygenless operation) was added 1.0 mmol3, 6-diiodetetrazine,2.2 mmol 3-methyl-4-iodopyrazole, 0.03 mmol palladium acetate, 0.06 mmol(3′-dimethoxy-2 ‘, 4′, 6′-triisopropyl (1,1′-biphenyl) -2-yl) phosphine, 5.0 mmol of sodium tert-butoxide And 5 ml of toluene, the reaction tube was purged with nitrogen three times and then heated to 110 C with an oil bath under magnetic stirring,The reaction was refluxed for 18 hours. To the room temperature; the reaction solution was further added, 8.0 mmol of 3,5-dicarboxyphenylboronic acid,0.03 mmol palladium acetate, 0.06 mmol 2′-dicyclohexyl-2,6-dimethoxy-3-sulfonic acid-1,1’-biphenyl sodium salt,12.0 mmol of cesium carbonate, and 200 mmol of water; and then heated to 100 C with an oil bath under magnetic stirring,The reaction was refluxed for 48 hours. Down to room temperature; add 20 ml of water, filtration, with concentrated hydrochloric acid to adjust the pH of the filtrate to 1,After stirring at room temperature for 6 h, the mixture was filtered, washed with ethanol and dried to give product 8 with a yield of 76%.The mass spectrum (ESI) of the product (C26H18N8O8) was 570.12.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Iodo-3-methyl-1H-pyrazole, and friends who are interested can also refer to it.
Reference:
Patent; Luoyang Normal College; Li Hongmei; Xu Chen; Wang Zhiqiang; Tu Tianyong; Hao Xinqi; (10 pag.)CN106674208; (2017); A;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics