Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C6H8N2O2
Preparation 1: Synthesis of 1-(1H-indol-5-yl)pyrazole-4-carboxylic acid ethyl ester; [286] [287] 1H-pyrazole-4-carboxylic acid ethyl ester (1.00g, 7.14mmol) and 1H-indol-5-ylboronic acid (1.15g, 7.14mmol) were dissolved in N,N-dimethylformamide (70mL). Cupper (II) acetate (0.972g, 5.35mmol) and pyridine (1.2mL, 14.8 mmol) were added, and the mixture was stirred for 3 days at room temperature. The solvent was distilled off under reduced pressure and the residue was purified by column chromatography to give the title compound (1.40g, 5.47mmol, 77% Yield). [288] NMR: 1H-NMR(CDCl3) delta 8.39(1H, s), 8.30(1H, br), 8.11(1H, s), 7.92(1H, d), 7.54(1H, dd), 7.47(1H, d), 7.31(1H, t), 6.64-6.62(1H, m), 4.35(2H, q), 1.39(1H, t) [289] Mass(EI) 256(M++1)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; LG LIFE SCIENCES LTD.; SONG, Jeong Uk; KIM, Geun Tae; CHOI, Sung Pil; JUNG, Cheol Kyu; PARK, Deok Seong; CHOI, Eun Sil; KIM, Tae Hun; PARK, Hyun Jung; PARK, Wan Su; PARK, Heui Sul; KOO, Ki Chul; ARTEMOV, Vasily; WO2011/43568; (2011); A2;,
Pyrazole – Wikipedia,
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