Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127107-23-7, SDS of cas: 127107-23-7
To a 25 mL round-bottom flask containing a solution of intermediate 20.1 (110 mg, 0.27 mmol, 1.00 equiv) in n-Butanol (6 mL) was added 1-methyl- 1H-pyrazol-4-amine hydrochloride (103.2 mg, 0.77 mmol, 2.85 equiv) at room temperature under nitrogen. The reaction was stirred overnight at 110 C in an oil bath. After cooling, the resulting mixture was concentrated under vacuum and resulting crude was purified using flash column chromatography to furnish 120 mg (95%) of compound 1-21 as a yellow solid. LCMS (ES, m/z): 467 [M+H] ?H NMR (400MHz, CDC13): 5 9.02 (1H, s), 7.81 (1H, s), 7.46 (1H, s),7.43 (1H, brs), 4.05-3.93 (1H, m), 3.79 (3H, s), 2.98 (2H, q), 2.53-2.50 (4H, m), 2.39-2.28 (1H, m), 2.05-1.94 (2H, m), 1.85 (2H, d), 1.58-1.30 (8H, m), 1.31 (3H, t), 0.23 (4H,s).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Methyl-1H-pyrazol-4-amine hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; NIMBUS IRIS, INC.; ROMERO, Donna L.; MASSE, Craig E.; ROBINSON, Shaughnessy; GREENWOOD, Jeremy Robert; HARRIMAN, Geraldine; WO2015/48281; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics