Research on new synthetic routes about 1572-10-7

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1572-10-7, name is 3-Amino-5-phenylpyrazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H9N3

Compounds8a-e(4.12 g, 20mmol) were dissolved in 30 mL of ethanol followed by the addition of 3-amino-5-phenylpyrazole(3.18 g, 20mmol) and three-four drops ofHCl. Then the reaction mixture was refluxed at ethanol temperature for 2 h. The reaction mixture was allowed to cool to room temperature, and the precipitated product was collected by vacuum filtration and washed with ethanol (3mL) thenrecrystallizedfrom ethanol to afford pure compounds9a-eas yellow solids in good yields.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Kamal, Ahmed; Faazil, Shaikh; Hussaini, S.M. Ali; Ramaiah, M. Janaki; Balakrishna; Patel, Nibedita; Pushpavalli; Pal-Bhadra, Manika; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 2077 – 2083;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics