Synthetic Route of 37622-90-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, This compound has unique chemical properties. The synthetic route is as follows.
Step A: tert-Butyl 4-[(methylsulfonyl)oxy]piperidine-1-carboxylate (3.62 g, 13.0 mmol) was combined with ethyl 4-pyrazolecarboxylate (2.0 g, 14 mmol) in 50 mL of DMF. The mixture was cooled to 0 C., and sodium hydride (467 mg, 19.5 mmol) was added. The reaction mixture was then heated at 50 C. for 10 h. Afterwards, it was diluted with diethyl ether (100 ml), washed with water (5×100 mL) and brine (1×10 mL), dried over magnesium sulfate, filtered, and concentrated in vacuo. Purification by MPLC (silica gel, 5-100% EtOAc/hexanes) afforded the desired product. ESI-MS calculated for C16H25O4: 323.39. found 346 (M+Na).
The chemical industry reduces the impact on the environment during synthesis Ethyl 4-pyrazolecarboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Goble, Stephen D.; Mills, Sander G.; Yang, Lihu; Pasternak, Alexander; US2007/238723; (2007); A1;,
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