Related Products of 92525-10-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 92525-10-5, name is 3-Iodo-1-methyl-1H-pyrazole belongs to pyrazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
To a mixture of the ail above brown solid, Pd(PPh3 )2Cl2 (31 mg, 0.044 mmol) and Cu l (8 mg, 0.044 mmol) in DMF (2 mL) under N2 atmosphere was added a solution of 3-iodo-l – methyl- 1 f-pyrazole (170 mg, 0.817 mmol) and triethylamlne (179 mg, 1.77 mmol) in DMF (1 .5 mL), The resulted mixture was heated to 80 C and stirred further for 16 hours, then diluted with EtOAc (20 mL) and washed with water (20 mL x 2) and brine (20 mL). The separated organic phase was concentrated in vacuo and the residue was suspended in a mixture of PE/EtOAe (5/1 (v/v), 12 mL). The mixture was stirred at rt for 4 hours, then filtered and the filter cake was washed with PE (10 mL). The filter cake was dried in vacuo to give the title compound as an orange-yellow solid (139 mg, yield for two steps (Step 4 and Step 5): 72.8%). MS (ESI, pos. ion.) m/z: 234.1 [M+H]+; FontWeight=”Bold” FontSize=”10″ H NMR (400 MHz, DMSO-Lambda) delta (ppm): 8.22 (s, 1H), 7.79 (d, J = 2.2 Hz, 1H), 6.64 (d, J = 2.2 Hz, 1H), 3.89 (s, 3H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Iodo-1-methyl-1H-pyrazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.; XI, Ning; WANG, Liang; WANG, Tingjin; WU, Weibin; (123 pag.)WO2015/175579; (2015); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics