Application of 37622-90-5,Some common heterocyclic compound, 37622-90-5, name is Ethyl 4-pyrazolecarboxylate, molecular formula is C6H8N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
[00615] To the solution of 196-1 (1 g, 7.1 mmol, 1 eq) in EtOH (6 mL) and H20 (10 mL) was added NaOAc (2.2 g, 27.1 mmol, 3.8 eq) and Br2 (5.1 g, 32.1 mmol, 1.7 mL, 4.5 eq). The mixture was stirred at 10 C for 16 hr. The reaction was monitored by TLC. To the reaction mixture was added sodium thiosulfate (2 g), and the solvent was evaporated under reduced pressure. The reaction mixture was poured into water, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, and dried over Na2S04. The solvent was evaporated under reduced pressure to give 196-2 (1.8 g, crude).
The synthetic route of 37622-90-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VIVACE THERAPEUTICS, INC.; KONRADI, Andrei W.; LIN, Tracy Tzu-Ling Tang; (396 pag.)WO2018/204532; (2018); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics