Related Products of 18213-75-7, A common heterocyclic compound, 18213-75-7, name is 5-Amino-1-methyl-1H-pyrazole-4-carboxamide, molecular formula is C5H8N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
5-Amino-I-methyl-I H-pyrazole-4-carboxylic acid amide (1.49 g; 10.618 mmol and 4,4-dimethyl-dihydro-pyran-2,6-dione (2.26 g; 15.898 mmol) was heatedto 170 C for 6 h. The reaction mixture was cooled to room temperature, 10% aqueous sodium hydroxide solution (56.00 mL) was added and the mixture was heated to 100 C for 2h. The reaction mixture was cooled to 0 C, acidified with acetic acid and extracted with dichloromethane. The combinedorganic layers were dried with sodium sulfate, filtered by suction and concentrated. The residue was triturated with petrol ether and ethyl acetate (1/I), the resulting solid was filtered and dried. Yield: 0.80 g (28%) colorless solid: LC/MS (B), Rt: 1.84 mm; (M+H) 265.0. ?H NMR (400 MHz, DMSO-d6) 6 13.00 (brs, IH), 12.12 (brs, IH), 7.92 (s, IH), 3.86 (s, 3H), 2.68 (5, 2H), 2.22(s, 2H), 1.04 (s, 6H)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; MERCK PATENT GMBH; BUCHSTALLER, Hans-Peter; DORSCH, Dieter; (111 pag.)WO2017/76484; (2017); A1;,
Pyrazole – Wikipedia,
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