These common heterocyclic compound, 63874-95-3, name is 1-Benzyl-1H-pyrazole-4-carbaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 1-Benzyl-1H-pyrazole-4-carbaldehyde
in room temperature, 1-Benzyl-1H-pyrazole-4carboxaldehyde (18.6 g, 0.1 mol), sodium bromate (7.5 g, 0.05 mol) and 200 g of acetic acid were mixed, and 50 g of ammonia water having a molecular weight concentration of 25% of ammonia was added. 300 ml of water, heated to 90 C, the reaction is exothermic, maintain the reaction temperature of 100 C, reflux reaction for 1 hour to 1-benzyl-1H-pyrazole-4 formaldehyde complete reaction, cooled to room temperature, the reaction solution was poured into ice water After quenching and dilution, the mixture was neutralized until the reaction liquid was neutral, extracted with dichloromethane, dried, and concentrated, and then distilled under reduced pressure and recrystallized to give a product of 16.6 g, yield 91%, purity 98% or more.
The synthetic route of 1-Benzyl-1H-pyrazole-4-carbaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Changsha Luxing Biological Technology Co., Ltd.; Tan Yongjun; (14 pag.)CN108707113; (2018); A;,
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