Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 37687-24-4, name is Diethyl 3,5-pyrazoledicarboxylate, This compound has unique chemical properties. The synthetic route is as follows., Safety of Diethyl 3,5-pyrazoledicarboxylate
Example 4: ethyl 4-hydroxy-6-methyl-pyrazolo[l,5-a]pyrazine-2-carboxylate (0257) l-Chloropropan-2-one (10.5 kg, 113 mol) was added slowly at room temperature (0258) (exothermic) to a suspension of diethyl lH-pyrazole-3,5-dicarboxylate (20 kg, 94.2 mol) and cesium carbonate (30.7 kg, 94.2 mol) in acetone (200 1). The reaction mixture was stirred for 1.5 hours, filtred and the precipitate was washed with acetone. Acetone was distilled off from the filtrate at 60 C to obain a volume of 60-90 1, DMSO (85 1) was added and the distillation was continued until acetone was completely removed. (0259) Ammonium acetate (14.5 kg, 188 mol) was added at room temperature. The reaction mixture was stirred at 80 C for 18 hours, cooled to 60 C and water (290 1) was slowly added. The suspension was stirred 2 hours at 0-5 C. The precipitate was filtered off, washed with water and dried at 70 C under high vacuum affording ethyl 4-hydroxy-6- methyl-pyrazolo[l,5-a]pyrazine-2-carboxylate (16.8 kg, 80.6%) as beige crystals. (0260) 1H-NMR (600 MHz, DMSO-d6): 11.51 (s, 1H), 7.62 (s, 1H), 7.32 (s, 1H), 4.33 (q, 2H), 2.14 (s, 3H), 1.32 (t, 3H); MS(ISP): m/e = 222.09 (M+H+).
According to the analysis of related databases, 37687-24-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; DOTT, Pascal; FEYEN, Fabian; HILDBRAND, Stefan; HOFFMANN, Ursula; HOFFMANN-EMERY, Fabienne; MEIER, Roland; MOINE, Gerard; REGE, Pankaj; WUITSCHIK, Georg; (64 pag.)WO2017/186668; (2017); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics