Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 55864-87-4, name is Ethyl 4-nitro-1H-pyrazole-3-carboxylate, A new synthetic method of this compound is introduced below., Recommanded Product: 55864-87-4
a) Ethyl 4-NITRO-LH-PYRAZOLE-3-CARBOXYLATE (741 mg, 4 mmol) was heated at 90C with a concentrated solution of aqueous ammonia (28%, 20 ML) in a sealed vessel for 3 hours. The mixture was evaporated and the residue was triturated with diethyl ether to give 4-NITRO-LH- pyrazole-3-carboxamide (0.54 g, 86% yield) as a white solid: 1H-NMR (DMSO d6) : 8. 70 (s, 1H), 8.06 (s, 1H), 7. 83 (s, 1H); MS (+VEESI) : 157.13 (M+H) +.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/94410; (2004); A1;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics