Adding a certain compound to certain chemical reactions, such as: 127107-23-7, name is 1-Methyl-1H-pyrazol-4-amine hydrochloride, belongs to pyrazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 127107-23-7, Safety of 1-Methyl-1H-pyrazol-4-amine hydrochloride
2-((6-((2,5-dichloropyrimidin-4-yl)amino)hexahydrofuro[3,2-b]furan-3-yl)oxy)ethanol (0.18 g, 0.54 mmol) was suspended in n-BuOH (5 mL) and 1-methylpyrazol-4-amine hydrochloride (0.15 g, 1.10 mmol) and N,N-diisopropylethylamine (0.28 g, 2.18 mmol) were added thereto. The mixture was placed in a sealed tube and then heated to 150 C with stirring overnight and then concentrated under reduced pressure. The residue was purified by silica gel column chromatography (DCM / MeOH (v / v) = 20/1). The title compound was obtained as a brown viscous liquid (42 mg, 20%).
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Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jiatuo Sciences Corporation; Xi Ning; Li Minxiong; Li Xiaobo; Dai Weilong; Wang Tingjin; (74 pag.)CN104926824; (2017); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics