Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 54605-72-0, name is 1-Phenylpyrazole-4-carboxaldehyde, A new synthetic method of this compound is introduced below., Recommanded Product: 1-Phenylpyrazole-4-carboxaldehyde
General procedure: To a well stirred mixture of 2,6-difluoro-3-aminobenzamide(10) (0.17 g, 1.0 mmol) and 3-n-butoxybenzaldehyde (0.17 g,1.0 mmol) in MeOH (10 mL) at 0 C, was added p-toluenesulfonicacid monohydrate (0.02 g, 0.11 mmol) and the reaction mixturewasstirred for 2 h. After that, excess sodium cyanoborohydride (0.63 g,10.0 mmol)was added in portions to the reaction mixture. After theaddition, the reaction mixture was stirred for further 12 h. The reactionwas quenched by pouring into a separating funnel containing50 mL water and extracted with ethyl acetate (20 mL x 3). Thecombined organic layers were dried over MgSO4, filtered andevaporated under reduced pressure to a crude product, which wassubjected to purification by flash column chromatography on silicagel with gradient elution (20%e50% ethyl acetate in hexane) toafford the titled compound (0.15 g) in 45% yield.
The synthetic route of 54605-72-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lui, Hok Kiu; Gao, Wei; Cheung, Kwan Choi; Jin, Wen Bin; Sun, Ning; Kan, Jason W.Y.; Wong, Iris L.K.; Chiou, Jiachi; Lin, Dachuan; Chan, Edward W.C.; Leung, Yun-Chung; Chan, Tak Hang; Chen, Sheng; Chan, Kin-Fai; Wong, Kwok-Yin; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 95 – 115;,
Pyrazole – Wikipedia,
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