Synthetic Route of 129768-30-5,Some common heterocyclic compound, 129768-30-5, name is Ethyl 3-(Trifluoromethyl)pyrazole-5-carboxylate, molecular formula is C7H7F3N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of ethyl 3-(trifluoromethyl)-lH-pyrazole-5-carboxylate (2 g, 9.615 mmol, 1 eq) in THF (30 ml) was added LiAlH4 (1.09g, 28.846 mmol, 3 eq), portionwise at 0C for 10 min. The RM was stirred at RT for 2h.The RM was quenched with sat Na2S04 (50 ml) and most of the solvent was removed under reduced pressure. The residue was diluted with water (100 ml) and extracted with EtOAc (3x 100 ml). The combined organic layers were washed with brine (100ml), dried(Na2S04) and concentrated to afford the title compound (1.5 g, 94%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 3-(Trifluoromethyl)pyrazole-5-carboxylate, its application will become more common.
Reference:
Patent; GRUeNENTHAL GMBH; SCHUNK, Stephan; REICH, Melanie; KOENIGS, Rene, Michael; (72 pag.)WO2017/59966; (2017); A1;,
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