Reference of 120068-79-3, A common heterocyclic compound, 120068-79-3, name is 5-Amino-1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-1H-pyrazole-3-carbonitrile, molecular formula is C11H5Cl2F3N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4. Add CF3SOCl to the appropriate reagent, react, heat up, and then add 99.5% of 5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole. And a mixture of p-toluenesulfonic acid dimethylamine salt, while adding a catalyst, and reacting for 10 hours, the solvent was evaporated under reduced pressure to obtain 98-99% of fipronil.
The synthetic route of 120068-79-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Jiangsu Tuoqiu Agrochemical Co., Ltd.; Shan Xiaojun; Chen Yunshan; Xu Lidong; Liao Dazhang; (4 pag.)CN104557713; (2018); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics