Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1453-58-3, name is 3-Methylpyrazole, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 3-Methylpyrazole
250 mL of dimethyl sulfoxide and sodium hydride 24.0 g (60percent, petroleum ether washing) were added to a three-necked flask, and 41.0 g of 3-methylpyrazole was dissolved in 150 mL of dimethyl sulfoxide, and slowly added to the reaction flask. The reaction was carried out until no bubbles were evolved, and 101.5 g of p-methoxybenzyl bromide was added to maintain the temperature of the reaction system at 30 °C. After the reaction was completed, 1 L of ice water was added, and dichloromethane (200 mL × 3) was added, and the organic phase was combined, washed with water, washed with saturated sodium hydrogen carbonate, brine, and dried over anhydrous sodium sulfate.Concentration gave 99.6 g (98.5percent) of 1-(4′-methoxybenzyl)-3-methylpyrazole.
According to the analysis of related databases, 1453-58-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Nantong University; Tang Yanfeng; Ding Xinyu; Shan Jiahui; Yu Hongmei; Wang Shuqing; Mao Jiarong; Guo Xiaoqing; (5 pag.)CN103880749; (2019); B;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics