Synthetic Route of 75415-03-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 75415-03-1, name is 2-(1H-Pyrazol-3-yl)pyridine, This compound has unique chemical properties. The synthetic route is as follows.
General procedure: Compound 4a (2 mmol), NaH (2.4 mmol) and indole were dissolved in DMF (10 mL). The reaction mixture was stirred at room temperature for 12h before diluted with water (20 mL) and extracted with ethyl acetate (30 mL × 3). The organic layer was concentrated in vacuum. Purication by ash column chromatography gave the target product 5h.
The chemical industry reduces the impact on the environment during synthesis 2-(1H-Pyrazol-3-yl)pyridine. I believe this compound will play a more active role in future production and life.
Reference:
Article; Wang, Chen-Ru; Wang, Ze-Feng; Shi, Lu; Wang, Zhong-Chang; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry Letters; vol. 28; 14; (2018); p. 2382 – 2390;,
Pyrazole – Wikipedia,
Pyrazoles – an overview | ScienceDirect Topics